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Fukuda A, Deshpande SB, Shimano Y, Nishino H

To address cytokine storms, drugs like corticosteroids, including prednisone, are frequently used to mitigate inflammation

On neutrophil activation, the PPP is promoted, alongside glycolysis, to supply NADPH for antibacterial activity

They are periodically replaced by a single layer of basal keratinocytes, which proliferate constantly and give birth to cells that ascend toward the skins surface

GDF15 regulates the metabolic pathways of macrophages, acquiring an anti-inflammatory function dependent on oxidative phosphorylation, reducing the expression of pro-inflammatory factors, and decreasing the infiltration of monocytes and neutrophils into the liver, thereby alleviating liver inflammation [174, 175]