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The main characteristics of chronic kidney disease (CKD) include progressive renal tissue structural lesions and impaired renal excretory function, which may be due to functional nephron defects caused by diverse causative variables, including diabetes, interstitial nephritis, glomerulonephritis, obstructive nephropathy and polycystic kidney disease (116)

Additionally, the excessive production of CXCL13 and vascular VEGF by macrophages can also promote tissue fibrosis, immune activation and abnormal vascular morphology in SSc (156, 157)

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