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Its advantages in overcoming drug resistance are: 1) Oral formulations are delivered through albumin binding or nanocarriers to avoid insufficient uptake caused by low hENT1 expression (D et al., 2025), and in pancreatic cancer models, the efficacy is 30% higher than that of intravenous formulations

Data from adipocyte culture systems demonstrate insulin-stimulated Ras farnesylation drives both adipogenic differentiation programs and glucose transport mechanisms through extracellular signal-regulated kinase 1/2 (ERK1/2) activation (194, 195)