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1 Introduction The World Health Organization (WHO) estimates that antimicrobial resistance (AMR) could cause up to 10 million deaths annually by 2050, with a severe impact on global healthcare costs and economic stability

This mitochondrial targeting enhances copper uptake by 50% compared to non-targeted analogs, leading to pronounced DAMP release and M1 macrophage polarization

The main areas affected by ASCVD are 1) CHD, 2) cerebrovascular disease, and 3) peripheral vascular disease (Tannu et al., 2024)

That distinction matters enormously for understanding both its benefits and its limitations

Ahmet I, Sawa Y, Iwata K and Matsuda H (2002) Gene transfection of hepatocyte growth factor attenuates cardiac remodeling in the canine heart: A novel gene therapy for cardiomyopathy