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In a placebo-controlled clinical study, a 5% ALA cream delivered via a nanostructured lipid gel significantly reduced facial wrinkles and fine lines in adult volunteers after regular use

10.1046/j.1471-4159.2003.02029.x 69 HalliwellB.GutteridgeJ

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A mechanical or spring-loaded mechanism pushes a measured volume of solution through a short, ultra-fine needle into the subcutaneous fat layer just beneath the skin