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While some studies suggest benefits, human trials are still lacking

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Consistently, animal studies and clinical imaging have provided evidence that disrupted MET signaling produces functional as well as morphological alterations in neurons in those brain regions implicated in ASD endophenotypes (reviewed in Mutations in both HGF and MET genes are also linked to non-syndromic hearing impairment (NSHI), which is a partial or total loss of hearing that is not associated with other signs and symptoms

The JCA report is a 154-page document that describes the medical condition and drug product, assesses the evidence on the treatment, and includes appendices about the joint clinical assessment process

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