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Due to the high reaction specificity and orthogonality of the CuAAC click reaction, this two-component stapling strategy can incorporate crosslinks with different chemical properties and functionalized modifications through double-click reactions involving two side chains with azido functional groups at the i , i + 4, or i + 7 positions and a dialkynyl linker

Zakrzewicz A, Secomb TW, Pries AR (2002) Angioadaptation: keeping the vascular system in shape

The rats were obtained from the Experimental Animals Application and Research Center of Erzincan Binali Yildirim University

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For moderate to darker skin tones, higher doses around 1200 mg or more might be suggested