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The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal

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Notably, PTGIS expression is elevated in the early stages of CCl 4 -induced liver fibrosis mice models only to be downregulated at a later stage ( 3.6 Sad1/UNC84 domain-containing protein 2 (SUN2) SUN2, is an inner nuclear membrane protein with an evolutionarily conserved Sad1/UNC-84 homology (SUN) domain at the C-terminus of the protein ( 4 -induced liver fibrosis mice, DNMT3b mediates hypermethylation of the SUN2 gene at CpG sites, leading to a reduction in SUN2 expression, induction of HSC activation, and liver fibrosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Lu S.C., Alvarez L., Huang Z.-Z., Chen L., An W., Corrales F.J., Avila M.A., Kanel G., Mato J.M