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In summary, these data suggest that glutathione plays a vital role in the detoxification of BH3 mimetics and that perturbation of GSH metabolism increases the sensitivity of AML cells towards BH3 mimetics

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Vyas et al, 1999), we decided to inhibit the expansion and infiltration of eosinophils also by a pharmacological approach and administered a neutralizing anti-IL-5 antibody on days 5 and 12 p.i