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Rutin Ameliorates Carbon Tetrachloride (CCl4)-Induced Hepatorenal Toxicity and Hypogonadism in Male Rats

Li J, Mahdi F, Du L, Datta S, Nagle DG, Zhou YD

Effective degradation of EGFRL858R + T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems

Statistical significance was tested using an unpaired two-tailed Students t test, a MannWhitney U test, a one-way or two-way ANOVA with Bonferroni correction or a KruskalWallis test followed by Dunns correction as indicated in the figure legend

These two studies (references 71 and 72) emanating from different groups and published within 12 months of each other used novel strains of NOX1-deficient mice to provide the first definitive evidence that NOX1 oxidase is an important contributor to angiotensin II-dependent hypertension and its associated vascular pathologies