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The authors suggested that the adduction of Grxs by EdAG suggests the possible alteration of proteins that are normally regulated via Grx-dependent reversible glutathionylation or deglutathionylation

Treatment with 17-estradiol or an agonist of the G protein-coupled estrogen receptor enhances CaM expression level substantially in ECs and promotes eNOS activity by moderating Ca 2+ entry and efflux, enhancing eNOS-CaM interaction and associated eNOS phosphorylation (Tran, 2020

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We have found that the greatest differences between the male and female responses are in the moderate to high range, which is why we show responses to 15 and 18 g in Figure 4