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This and other work indicates that imbalances between excitatory and inhibitory synaptic activity might form a prominent aspect of the pathomechanism 22

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Considering that the rate constant of superoxide radical dismutation by SOD1 is 2 10 9 M 1 s 1 and assuming concentrations of SOD1 and vitamin C = 10 M and 5 mM, respectively, vitamin C removes approximately 8% of the cytoplasmic superoxide radical

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