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One possible improvement (intrinsically offered by the time-domain approach since the arrival time of detected photons encodes the average investigated depth 9 ) could be the use of DTOF derived optical properties and/or magnetic resonance imaging derived information on the head geometry, which could both lead to defining optimal gate parameters on an individual basis

As tau becomes hyperphosphorylated, its capacity to support microtubule assembly and stability diminishes, resulting in increased levels of unbound tau that may aggregate into tangles (if not secreted or degraded in the lysosome) [107]

Neutrophil extracellular traps drive osteoporosis via NCF2-dependent signaling: integrated transcriptomics with mechanistic validation