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12.8 Pathway for biosynthesis and degradation of 2,3-bisphosphoglycerate (2,3-BPG)

B12 is water soluble and excreted in the urine, any excess would not build up in the body but be removed via urine

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The discovery of the overlap between tumor suppressor mechanisms and anti-angiogenic regulation in shark livers demonstrates potential benefits against atherogenesis by limiting irregular angiogenesis and neovascularization of atherosclerotic plaque growth that characterizes the advanced stages of atherosclerosis [52]

Mol Gen Metab 80 (4): 408-11 (2003)