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By further stimulating glucose uptake, suppressing the release of fatty acids from adipose tissue, and promoting fat and glycogen production, hyperinsulinemia following carbohydrate intake induces a vicious cycle that offers an explanation for why average BMI in many countries increased in the late 20th century as public health guidelines recommended replacement of dietary fat with carbohydrates, and consumption of high-glycemic-load foods increased substantially [51]

Melatonin as a coadjuvant in the treatment of patients with fibromyalgia

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Acknowledgments The authors thank the administrative staff (Roberta Saragozza and Fabiola Lobinu) for the formalization of the collaboration contracts, Gaetano Malgieri (DISTABiF