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increased antitumor activity in vivo when compared to EGFR inhibition alone was shown by Guo et al

Despite the potential of these novel therapies, the article acknowledges several limitations, including the variability in patient responses and the challenges of long-term adherence to treatment regimens

The meta-analysis, which pooled data across multiple studies using a random-effects model, found that lower B12 was significantly associated with metabolic syndrome markers including elevated blood pressure, elevated fasting glucose, and abnormal lipid profiles

The approach prioritizes long-term restoration over short-term symptom suppression

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