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Description

J Biol Rhythms (2005) 20(5):391403

Animal model research indicates that IGF-1 may protect against cellular aging and promote long-term metabolic benefits

Importantly, these studies demonstrate that the inactivation of mTORC1 is not a passive process, due to the absence of positive signals, but rather involves the active participation of key cellular mechanisms, such as the nutrient starvation- and stress-induced lysosomal relocalization of the TSC complex