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For the first time, medications are offering results that begin to approach those of more intensive interventions

Some studies employ mixed-strain probiotic formulations, precluding the isolation of the independent therapeutic effects of Clostridium

Topical applications appear generally well-tolerated in small studies, but systemic safety, long-term effects, and drug interactions remain inadequately characterized

In a randomized clinical study involving 75 women, sublingual Epitalon was administered at a dose of 0.5 mg/day for 20 days, with placebo and control cohorts for comparison