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After a follow-up period exceeding ten years, it was found that the local-regional recurrence (LRR) in the group receiving radiotherapy alone was slightly higher than those who underwent BCS followed by radiotherapy or mastectomy

Problem: Increased Fine Lines or Wrinkles Temporary increase in fine lines during weeks two through six can reflect normal collagen remodeling

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Many long-term studies have shown that metformin is safe and causes very few side effects

Environmental stochasticity (e.g., weather, species interactions) also contributes to substandard conditions in the local environment and may affect changes in both dispersal and general behavior (e.g., aspects of phenology including migration and breeding)