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A direct comparison between intranigral versus intrastriatal grafts using ventral mesencephalon (VM) fetal donor cells (Droguerre et al., 2022) or human ESC-derived midbrain DA neurons (Xiong et al., 2021) after 6-Hydroxydopamine (6-OHDA) injection into the SNpc in adult mice showed that, while both sent projections to appropriate dopaminergic targets, the intranigral grafts promoted better survival of DA neurons and the recovery of fine motor skills, whereas the intrastriatal grafts elicited higher inflammation/gliosis response at the site of the graft (Droguerre et al., 2022

Score

11 and Supplementary Table 3)