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4.3 Cancer 4.3.1 TAMs and immunosuppression TAMs shape an immunosuppressive microenvironment by polarizing towards the M2 phenotype, a process driven by metabolic reprogramming, dysregulated signaling pathways, and intercellular interactions

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222, 223, 224, 225 Therefore, approaches to target epigenetic mechanisms should take into consideration of the potential impact of the tumor microenvironment and metabolism

Restoring the stress response and increasing survival in stressed humans could be achieved with treatment with vitamin C

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