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When the mitochondria cannot efficiently import and burn long-chain fatty acids due to membrane damage or carnitine depletion, the body is forced to rely on less efficient, anaerobic pathways for energy production

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This group includes eight water-soluble vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin)

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These findings illuminate the physiologic significance as well as pathogenic implications of microproteins, an emerging class of proteins from the dark proteome (Jiang et al, 2021