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Research has indicated that hormone replacement therapy is associated with a decreased prevalence of sleep apnea in postmenopausal women, even after controlling for confounding variables such as age, body mass index (BMI), and neck circumference (12)

Furthermore, the following studies have demonstrated an overexpression of matrix metalloproteinases (MMP-1, 2, 3, 7, 9 and 13) in human colorectal cancer (46) and gastric cancer (47)