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YangMLuoSYangJChenWHeLLiuDet al

(1997) Biochemistry 36 : 6437-6447 PubMed: 9174360 Search on PubMed DOI: Primary Citation Related Structures: 1GRT, 2GRT, 3GRT, 4GRT, 5GRT PubMed Abstract: Trypanosoma and Leishmania, pathogens responsible for diseases such as African sleeping sickness, Chagas' heart disease, or Oriental sore, are two of the very few genera that do not use the ubiquitous glutathione/glutathione reductase system to keep a stable cellular redox balance

Also, a substantial decrease in glutathione levels precedes the mitochondrial dysfunction and neuronal death found in Parkinsons disease, suggesting GSH depletion may initiate the subsequent impairment.It also suggests that increasing GSH levels may have potential benefit toward preventing diseases associated with mitochondrial dysfunction

This is why combining both produces greater than additive effects: they suppress both the homeostatic and the hedonic drives to eat

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