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Lipoic acid has been found to activate the insulin signaling cascade in cultured cells (3, 42, 43), increase GLUT4 translocation to cell membranes, and increase glucose uptake in cultured adipose and muscle cells (44, 45)

Gut microbiota: Animal models suggest that gut microbiota (e.g., Bifidobacterium) can modulate host urate metabolism by degrading urate precursors, highlighting the potential role of the gutkidney axis in hyperuricemia ( 2.2.4 Mechanisms of renal and intestinal urate reabsorption and excretion Renal and intestinal handling of urate relies on specific transporters to maintain systemic urate levels

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It has a wide range of physiological effects and can affect multiple biological pathways including cardiovascular, neurological, and immune systems

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