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10.1124/jpet.109.160663 45 KorbeckiJ.Baranowska-BosiackaI.GutowskaI.ChlubekD

29 Although research has failed to consistently show a clinically significant risk to patients receiving G6PD-deficient donor blood, blood banks generally do not accept G6PD-deficient blood donors

Thus, the allergy is not to the original drug, but to a drug-protein complex

Ipamorelin hits the GHRP receptor and says "release GH now." CJC-1295 (no DAC) hits the GHRH receptor and says "amplify that release." When dosed together: CJC-1295 primes the pituitary and increases the available pool of GH Ipamorelin triggers the acute release of that pool The combined pulse is substantially larger than either compound generates alone research suggests synergistic effects in the range of 210x depending on baseline GH status and dosing This works because the two compounds bind to completely separate receptors