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The obtained data matrix was exported and quantification performed in Microsoft Excel 2016 by dividing the peak area of the identified lipid by the peak area of the corresponding internal standard, multiplied by the concentration of the internal standard

doi: 10.1016/j.brainresbull.2005.07.011 2 CampbellDBBuieTMWinterHBaumanMSutcliffeJSPerrinJMet al

Conclusions In summary, our results show that the use of COCs containing EE and DRSP causes shifts in endogenous estrogen biotransformation that result in a relative increase in the rate of estrogen conjugation, hydroxylation, and methylation, especially for E1

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