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Mechanically, chronic hypoxia promoted the transcriptional expression of Acer2 by activating HIF-2

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The development of biomarkers and imaging tools capable of confirming synaptic target engagement in vivo will be critical for successful clinical translation (Jackson et al., 2019)

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HGF is a pleiotropic factor produced by mesenchymal cells in the stroma and as such is widely distributed in the extracellular matrix (ECM) of most tissues [1, 8]