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Causality was established in preclinical in vivo experiments that, first, showed that down-regulating GSH levels through micro-injections of the GSH synthesis inhibitor buthionine sulfoximine in the nucleus accumbens impaired effort-based reward-incentivized performance

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Neuroprotective efficacy was evidenced by a 62% reduction in the loss of tyrosine hydroxylase+ neurons in the substantia nigra and substantial recovery of striatal dopamine and metabolites

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