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Furthermore, environmental particulate matter has the ability to cross the blood-brain barrier and penetrate the nasal mucosa epithelium, activating the nervous system by binding to particular receptors and producing oxidative stress (Lucchini et al., 2012)

Asiatic acid inhibits rheumatoid arthritis fibroblast-like synoviocyte growth through the Nrf2/HO-1/NF-B signaling pathway

Increased mitochondrial biogenesis (stimulates PGC-1 activation through stimulation of NO by guanylate cyclase) (144) and changes the muscle fiber type to a more oxidative phenotype when combined with the SIT [through the role of nuclear factor activated T cells (NFAT)calcineurin] (145147)

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