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In addition to direct health consequences (Triage response) attributed to inadequate micronutrient intake, an extension to the Triage Theory is that micronutrient deficiencies such as inadequate zinc can impair the cellular responses to environmental stresses, such as toxic metals exposure to exacerbate negative health outcomes

Methods 318 , 3746 (2007)

It has been shown that PD-1 blockade for neoadjuvant therapy leads to the upregulation of T cells and IFN genes within the tumor and the reduction of the cell cycle in rGBM, thereby promoting anti-tumor responses [533]

Since prolyl 4-hydroxylation is, however, the single most prevalent post-translational modification in humans [33], we will focus on prolyl 4-hydroxylases within the present review