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Myo-inositol Myo-inositol belongs to the vitamin B complex
Therefore, hyper nutrition diet along with increased mitochondrial acetyl-CoA, JNK activation, and interaction with SAB could enhance the citric acid synthesis and could export citric acid out of the mitochondria into cytosol for de novo fatty acid synthesis and cholesterol biosynthesis AcAc: acetoacetate ACC2: acetyl-CoA carboxylase 2 ACLY: ATP-citrate lyase ACO: aconitase ACOT: acyl-CoA thioesterases ACP: acyl carrier protein ACSS1: acyl-CoA synthases short-chain family member 1 AMP: adenosine monophosphate AMPK: adenosine monophosphate-activated protein kinase cAMP: cyclic adenosine monophosphate cGPD: cytosolic glycerol-3-phosphate dehydrogenase CPT-I: carnitine palmitoyl transferase-I CS: citrate synthase CYP27A1: cytochrome P450 family 27 subfamily A member 1 DHAP: dihydroxyacetone phosphate DRP1: dynamin-related protein 1 ER: endoplasmic reticulum ETC: electron transport chain FAD: flavin adenine dinucleotide FADH 2 : flavin adenine dinucleotide (reduced) FAO: fatty acid -oxidation FAODs: fatty acid -oxidation disorders FFAs: free fatty acids G3P: glycerol-3-phosphate GA3P: glyceraldehyde-3-phosphate GOTs: glutamate-oxaloacetate transaminases HFD: high-fat diet HMG: hydroxymethylglutaryl HMGCS2: hydroxymethylglutaryl-CoA synthase 2 HNF4: hepatocyte nuclear factor 4 IDH: isocitrate dehydrogenase IDHC: isocitrate dehydrogenase complex IMM: inner mitochondrial membrane JNK: c-Jun N-terminal kinase LCFAs: long-chain fatty acids LDL: low-density lipoprotein LXR: liver X receptor MAP2K: mitogen-activated protein kinase kinase MAPK: mitogen-activated protein kinase MASH: metabolic dysfunction-associated steatohepatitis MCFAs: medium-chain fatty acids MDH: malate dehydrogenase MFF: mitochondrial fission factor mGPD: mitochondrial glycerol-3-phosphate dehydrogenase mtFASII: mitochondrial fatty-acid synthesis type II MTHFD2: methylenetetrahydrofolate dehydrogenase 2 mTORC1: mammalian target of rapamycin complex 1 NASH: nonalcoholic steatohepatitis OAA: oxaloacetate OGDH: oxoglutarate dehydrogenase OGDHC: oxoglutarate dehydrogenase complex OMM: outer mitochondrial membrane PC: pyruvate carboxylase PDH: pyruvate dehydrogenase PDHC: pyruvate dehydrogenase complex PE: phosphatidylethanolamine PEP: phosphoenolpyruvate P-JNK: phosphorylated-c-Jun N-terminal kinase PKA: protein kinase A PTPN6: tyrosine-protein phosphatase non-receptor type 6 ROS: reactive oxygen species SAB/SH3BP5: SH3 domain-binding protein 5 sAC: soluble adenylyl cyclase SCFAs: short-chain fatty acids SDH: succinate dehydrogenase SIRTs: sirtuins SLC25A1: solute carrier family 25 member A1 SREBP1c : sterol regulatory element binding protein 1c StARD1/StAR: steroidogenic acute regulatory protein 1 TAG: triglyceride TCA: tricarboxylic acid THF: tetrahydrofolate -KG: -ketoglutarate -HB: -hydroxybutyrate Sanda W: Conceptualization, Investigation, Writingoriginal draft, Writingreview & editing, Supervision
Neurotox Res 23 , 267300 (2013)
