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The brain is prone to oxidative damage because it uses reactive species to transmit signals

Comparing semaglutide with alternatives Semaglutide is not the only GLP-1 agonist available

doi: 10.1161/01.HYP.0000221429.94591.72

This would align with previous studies in PSEN1 fibroblasts and iPSC-derived neurons from patients, where mitochondria were labeled correctly but unable to be degraded (Trushina et al., 2012)