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Reduced lipoapoptosis, Hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

Gautham Reddy 6 Christophe Corpechot 7 Susheela Carroll 8 Ke Yang 9 Daria Crittenden 8 Charles McWherter 9 , 1 Liver Institute Northwest, 2 California Pacific Medical Center, 3 Weill Cornell Medical College, New York, NY, 4 California Liver Reasearch Institiute, 5 Beth Israel Deaconess Medical Center, Boston, MA, 6 University of Chicago Medical Center, 7 Saint-Antoine Hospital, Paris, France, 8 CymaBay Therapeutics Inc, 9 CymaBay Therapeutics Background: Alkaline phosphatase (ALP) is an important marker in primary biliary cholangitis (PBC) associated with risk for disease progression

As a matter of fact, as a consequence of SIX1 down-modulation, glycolysis is reduced due to a decrease in glucose uptake, lactate and ATP production, extracellular acidification rate (ECAR) and an increase in oxygen consumption rate (OCR) [44]

Its ability to activate autophagy, leading to increased angiogenesis, reduced apoptosis, and diminished oxidative stress, is particularly notable Trehalose stimulates the expression of Vascular Endothelial Growth Factor (VEGF) and cadherin 5, alongside an increase in MMP9 expression, thereby augmenting the viability of skin flaps