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Hence, the upregulation of SIRT1 reduces COX-2 levels by inhibiting the activation of AP-1 and NF-B [344]

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Ding C, Ding X, Zheng J, Wang B, Li Y, Xiang H, et al

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Comparing the schistosomicidal activity against juvenile worms with that of PZQ reported in previous in vivo studies 61 , the inhibitors reported herein show superior schistosomicidal activity to PZQ at the worm developmental stage in mice