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Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan

The requirement of a protein pre- or post-organ and -animal development is an important distinction that is not always considered in studies involving tissue-specific knockout mouse models but potentially requires additional investigation

For instance, Diacylglycerol can directly bind to PKC, inducing a conformational change in PKC that results in the generation of phosphorylated PKC, subsequently activating the enzyme [39]

L.et al (2017)

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