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A prospective randomized controlled open trial of 75 breast cancer patients showed that oral NAC (1200 mg once and twice daily) was effective in reducing the incidence and severity of paclitaxel-induced peripheral neuropathy, accompanied by increased serum nerve growth factor (NGF) levels and decreased malondialdehyde (MDA) levels, which could prevent grade 3 neurotoxicity [68]

Outcome measures The primary outcome was the effect of KD on clinical phenotypes (epilepsy, muscle involvement, tonus dysregulation (muscular hyper- or hypotonia), movement disorders, developmental delay and intellectual disability (DD/ID), other individual signs and symptoms) and the occurrence of adverse events (AEs)

Pathway analysis indicated that these DEMs were primarily associated with glycine, serine, threonine metabolism, fatty acid biosynthesis, and ABC transporter pathways

[DOI] [PubMed] [Google Scholar] 100.Antolino-Lobo I., Meulenbelt J., Molendijk J., Nijmeijer S.M., Scherpenisse P., van den Berg M., van Duursen M.B

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