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GCL knockdown was insufficient to trigger a significant increase in mitochondrial O 2 , but this was strongly potentiated by rotenone and rescued by mito GCL (mut

After 4 weeks of observation, the tumor volume was recorded, and the tumors of the nude mice in each group were weighed

Telomeres are the protective caps on the ends of chromosomes that shorten every time a cell divides

Furthermore, kidneys from PKD1-knockout mice exhibit prominent features of ferroptosis, including the downregulation of SLC3A2, SLC7A11, and GPX4 and the upregulation of TFR1, divalent metal transporter 1, and HO-1, as well as mitochondrial abnormalities such as reduced mitochondrial cristae and ruptured mitochondrial outer membranes