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TMED4 is a potent activator of NRF2, and loss of TMED4 prevents NRF2 from inducing an antioxidant state within the cell

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Two studies showed that NAMPT protein expression is enhanced in skeletal muscle following exercise 326,327

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10.1111/j.1399-3054.1989.tb05668.x 158 TiwariS.LataC.ChauhanP

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