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(I went a few years, ordering levothyroxine from India with no prescription, managing it on my own, and going to a lab every 3 years or so to get a TSH.) In the past, any complete cessation of my thyroid medication (levothyroxine) would result in me hitting a wall of fatigue on about the 2nd or 3rd day off the medication

While -synuclein (-Syn), which is encoded by SNCA , is one of the fundamental components in the Lewy body, patients with SNCA mutants (A30P, E46K, H50Q, G51D, A53E, and A53T) or multiplications are really rare, characterized by autosomal dominant inheritance, widely distributed age of onset (from 19 to 81 years), and more rapid cognitive impairment (Rosborough et al., 2017)

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