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Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, et al

Processed foods can cause inflammation in your stomach, can alter the gut bacteria, such foods stay in the stomach for long, can decrease stomach acid activity, and trigger acid reflux symptoms

Changes in functional connectivity have also been shown using functional MRI, where functional connectivity between two regions is defined as the similarity (commonly Pearson correlation) between the BOLD signal from those regions-

Saleh HA, Yousef MH, Abdelnaser A

In one study, fatigue was also found to be the most important contributor to levels of physical functioning (81)