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Cibinetide (ARA-290): A More Preventative, Balanced Anti-Inflammatory Approach In contrast, cibinetide (ARA-290), when given systemically (typically via subcutaneous injection), circulates and reduces inflammation more directly through selective activation of the innate repair receptor (IRR) a heterocomplex (EPOR/-common receptor or CD131) that is upregulated primarily on cells in response to tissue injury, hypoxia, metabolic stress, or inflammation

The effects of tannic acid on cytochrome P450 and phase II enzymes in mouse liver and kidney

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Eur J Immunol (2005) 35:260816