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The clinical management is achieved by administering a high-fat diet (81), which sustains the production of ATP by mitochondria primarily through fatty acid -oxidation, bypassing PDH to directly enter the Krebs cycle

First, as an antiporter, SLC7A11-mediated cystine uptake is coupled with glutamate export (Fig

Traditional peptides are complete amino chains and often target a single pathway

Glutathione is one of our first lines of defense, a ubiquitous molecule, that is, present throughout our organism, but it is particularly concentrated at the liver level , where it protects the liver cells from toxic molecules: in this case, Glutathione "binds" to the toxic metabolites, neutralizing them

Relief of oxidative stress requires entry of glycolate into serineglycine metabolism According to the scheme in Fig