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doi: 10.1172/JCI154225 112 VaibhavKBraunMAlversonKKhodadadiHKutiyanawallaAWardAet al

It is unknown whether ZEPBOUND causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined [see Warnings and Precautions (5.1) and Nonclinical Toxicology (13.1)]

Metformin was also demonstrated to alter expression of genes involved in metabolism, specifically inhibition of oxidative phosphorylation genes, supporting functional analyses and highlighting metformin as a metabolic modulator in rectal cancer