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Older adults also have an increased risk of alcohol use disorder due to an increase in social isolation, divorce or bereavement, and increased rates of depression, reduced alcohol metabolism, and increased alcohol toxicity that lead to an increased risk of alcohol-associated liver disease and a worse prognosis with alcohol-associated liver disease among older adults

This suggests that the process of GSH-mediated ROS detoxification has important influence on the level of [ROS] during retinal development and degeneration

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has also increased alongside the obesity epidemic [13,22]