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doi: 10.1016/j.neulet.2022.137015, 35 YamamotoM.KenslerT

They reported that p53 suppresses accumulation of cytoplasmic chromatin fragments (CCF), including DNA damage signaling marker H2A.X, and its downstream inflammatory phenotype (e.g., SASP) of monocytes and macrophages in liver

The Synergy : Its a powerful one-two punch

Both HO-1 and its upstream regulator, nuclear factor erythroid 2-related factor 2 (Nrf2), are oxidative stress inhibitors (98100)

All procedures were approved and conducted per the University Committee on Animal Resources at the University of Rochester Medical Center (UCAR #2010-024E, UCAR-2008-016E)