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(5) Wessells H, Fuciarelli K, Hansen J, Hadley ME, et al

The MITF (microphthalmia-associated transcription factor) pathway is simultaneously upregulated downstream of PKA/CREB activation, serving as the master transcriptional regulator that coordinates the entire melanogenic enzyme cascade, and this cAMP-PKA-CREB-MITF axis represents the canonical signaling pathway measured in Melanotan II potency assays

The efficacy of chemoradiotherapy for this disease is uncertain, but there is some literature suggesting that stereotactic radiotherapy can be used to treat this disease, but more evidence-based evidence is lacking [8, 9]

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