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Thus, mTORC1 promotes the nuclear translocation of the cAMP response element-binding protein (CREB) which stimulates the transcription of the anti-apoptotic gene MCL-1 in the nucleus and the upregulation of the Bcl-2 family protein myeloid cell leukemia 1 (Mcl-1) [300]

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In the body, the overwhelming majority of circulating IGF-1 is not free it is bound to a family of six IGFBPs that regulate its availability, transport, and clearance, and that generally restrain its biological activity