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F.HampeN.HerschN.et al (2013)

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Drug-likeness assessments revealed that the Epothilone-GSH conjugate exhibited more violations of Lipinski's rule of five (3 violations) compared to Epothilone (1 violation), resulting in lower bioavailability scores of 0.11 and 0.55, respectively

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To summarize, different parameters affect the enzyme activity after plasma treatment, such as disruption of chemical bonds (such as disulfide and hydrogen bonds), changes in the secondary structure of the enzyme, changes in the PH of the environment, and different chemical modifications, such as ring-opening of amino acids, sulfonation, amidation, hydroxylation, and oxidation (Saremnezhad et al