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From the preclinical data for putative benefits there were also important side effects noted

Key SleepOptimizing Peptides and Their Evidence CJC1295 (a longacting GHRH analog), Ipamorelin, Sermorelin, and Delta SleepInducing Peptide (DSIP) mechanisms CJC1295 (a longacting GHRH analog) and Ipamorelin synergistically stimulate pulsatile growthhormone (GH) release from the pituitary, deepening slowwave sleep without raising cortisol

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Water retention commonly occurs during the first few weeks, causing temporary weight gain and possible joint stiffness